Information for KPV

KPV (Lys-Pro-Val) is a naturally occurring tripeptide derived from the C-terminal sequence of α-melanocyte-stimulating hormone (α-MSH) that inhibits NF-κB and MAPK inflammatory signaling pathways independently of melanocortin receptor activation (Dalmasso et al. 2008; Land 2012). Cellular uptake is facilitated by the H⁺-coupled oligopeptide transporter PepT1, through which KPV accumulates intracellularly and suppresses downstream pro-inflammatory cytokine expression, including TNF-α, IL-6, and IL-8 (Dalmasso et al. 2008). KPV has been investigated as a research tool in models of intestinal inflammation, including in targeted nanoparticle-based delivery systems (Xiao et al. 2017).

References
KPV Vial

GMP Certificates of Analysis

KPV

10.24mg

Batch V260409-12 001

4/28/2026

KPV

11.42mg

Batch V260127-3 005

2/16/2026

KPV-Peptide-Sequence-768x768

KPV Peptide Structure

Source: PubChem

PubChem Identifier: CID 90474670

Sequence: KPV

Molecular Formula: C18H34N4O6

Molecular Weight: 402.5 g/mol

Product Usage

This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.